中国科学院昆明植物研究所——孙汉董院士(2)

　　主要成就

　　率先开展了民间抗癌药物冬凌草的二萜类化学成分研究，迄至2002年，他的研究组及其合作者对我国51种香茶菜属植物的化学成分进行了研究，发现新化合物近400个，与有关单位合作发现了多种生理活性成分，为该属植物的化学成分和新药开发作出了贡献。近10多年来，他的研究组已成为世界该领域的植物化学研究中心，近10年来国内外出版的二萜天然产物的综述文章和著作中，60%以上的对映-贝壳杉烷类二萜化合物引自他的研究组的发现。其中以分子间氢键结合的二萜[Diterp-Complex-RA(DCRA),60(3)203-206,Journal of Natural product]被《Natural Product Reports》〔14(4)，309，0997〕杂志列为1997年的“研究热点”(Hot off the press);对三种国内红豆杉属植物的化学成分研究中，发现新化合物70个，为该类植物资源的合理开发利用提供了有价值的资料;对31种伞形科药用植物的香豆素类化学成分进行了系统研究，为这些植物的利用和质控标准提供了科学依据;对50余种香科植物的资源和化学成分进行了系统研究，是我国天然香料化学的主要学术带头人之一。

　　代表性论文如下：

　　1.河南省医学科学研究所，河南医学院，云南植物研究所(化学部分由孙汉董撰写)，一种新的抗肿瘤物质——冬凌草素，科学通报，1978, 23(1)：53-56.

　　2.Tetsuro Fujita, Sun Han-dong, Yoshio Takeda, Yoshinori Minami, Teruyoshi Marunaka, Lin Zhong-wen, Xu Yun-long. Structure of phyllostachysin A: Novel Antineoplastic Diterpenoid from Rabdosia phyllostachys. J. Chem. Soc. Chemical. Communincation, 1985: 1738-1739.

　　4.孙汉董，中国香料植物资源. 云南植物研究，《植物资源研究专集》(增刊I)，1988: 77-88;香料香精化妆品，1988, 3: 1-14; 香料(日本)，2000，207: 110-118.

　　5.Sun Han-dong, Qiu Sheng-xiang, Lin Long-ze, Zhang Rong-ping, Zhou Yasheen, Zheng Qi-tai, Michael E. Johnson, Harry H. S. Fong, Norman R. Farnsworth and Geoffrey A. Cordell. Crystal structure of a 1:1 complex of Natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol. Journal of Natural Product, 1997, 60(3): 203-206.

　　6.Sun Han-dong, Qin Sheng-xiong, B. Lobkovsky emil, Lin Long-ze, Norman R. Farhsworth, Jon Clardy and Harry H. S. Fong, Crystal and Molecular Structures of a natural equimolecular mixture of two epimeric diterpenes. Tetrahedron, 2001, 57(1): 65-70.

　　7.Li Rong-tao, Zhao Qin-shi, Li Sheng-hong, Han Quan-bin, Sun Han-dong*, Lu Yang , Zhang Li-li , and Zheng Qi-tai, Micrandilactone A, a novel triterpene from Schisandra micrantha. Organic Letters, 2003, 5: 1023-1026.

　　8.Shen Yun-heng, Li Sheng-hong, Li Rong-tao, Han Quan-bin, Zhao Qin-shi, Liang Li, Sun Han-dong*, Lu Yang, Cao Peng, Zheng Qi-tai. Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis. Organic Letters, 2004, 6 (10): 1593-1595.

　　9.Han Quan-bin, Lu Yang, Zhang Li-li, Zheng Qi-tai, Sun Han-dong*. Novel ent-kaurane dimers from Isodon rubescens var. rubescens. Tetrehedron Letters, 2004, 45 (13): 2833-2837.

　　10.Li Sheng-hong, Wang Jia, Niu Xue-mei, Shen Yun-heng, Zhang Hong-jie, Sun Han-dong*, Li Ma-lin, Tian Qin-e, Lu Yang, Cao Peng, Zheng Qi-tai. Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara. Organic Letters, 2004, 6 (23): 4327-4330.

　　11.Pu Jian-xin, Xiao Wei-lie, Lu Yang, Li Rong-tao, Li Hong-mei, Li Xian, Zhao Qin-shi, Zheng Qi-tai, Sun Han-dong*. Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton. Organic Letters, 2005, 7(22): 5079-5082.

　　12.Li Rong-tao, Han Quan-bin, Zheng Yong-tang, Wang Rui-rui, Yang Liu-meng, Lu Yang, Zheng Qi-tai, Zhao Qin-shi, Sun Han-dong*. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha. Chemical Communications. 2005, 23: 2936-2938.

　　13.Li Rong-tao, Xiao Wei-lie, Shen Yun-heng, Zhao Qin-shi, Sun Han-dong*. Structure characterization and possible bioggenesis of three new families of nortriterpenoids: Schisanartane, schiartane, and 18-norschiartane. Chemistry-A European Journal. 2005, 11 (10): 2989-2996.

　　14.Xiao Wei-lie, Li Rong-tao, Li Sheng-hong, Li Xiao-li, Sun Han-dong*, Zheng Yong-tang, Wang Rui-rui, Lu Yang, Zheng Qi-tai. Lancifodilactone F: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity. Organic Letters 2005, 7 (7): 1263-1266.

　　15.Sun Han-dong*, Huang Sheng-xiong, Han Quan-bin. Diterpenoids from Isodon species and their biological activities. Natural Product reports, 2006, 23: 673-698.

　　16.Huang Sheng-xiong, Xiao Wei-lie, Li Li-mei, Li Sheng-hong, Zhou Yan, Ding Li-sheng, Lou Li-guang, and Sun Han-dong*. Bisrubescensins A-C: Three New Dimeric ent-Kauranoids Isolated from Isodon rubescens, Organic Letters, 2006, 8(6): 1157-1160.

　　17.Huang Sheng-xiong, Yang Li-bin, Xiao Wei-lie, Lei Chun, Liu Jing-ping, Lu Yang, Weng Zhi-ying, Li Li-mei, Li Rong-tao, Yu Jun-lin, Zheng Qi-tai, and Sun Han-dong*. Wuweizidilactones A-F: Novel Highly Oxygenated Nortriterpenoids with Unusual Skeletons Isolated from Schisandra chinensis. Chemistry-A European Journal, 2007, 13, 4816-4822.

　　18. Li Li-mei, Li Guo-you, Ding Li-sheng, Lei Chun, Yang Li-bin, Zhao Yong, Weng Zhi-ying, Li Sheng-hong, Huang Sheng-xiong, Xiao Wei-lie, Han Quan-bin, Sun Han-dong*. Sculponins A-C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus. Tetrahedron Letters. 2007, 48(52): 9100-9103.

　　19. Wang Lan, Zhao W-l, Yan J-S, Liu P, Sun H-P, Zhou G-B, Weng Z-Y, Wu W-L, Weng X-Q, Sun X-J, Chen Zhu*, Sun Han-dong* and Chen Sai-juan*, Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappa B and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death and Differentiation, 2007, 14 (2): 306-317.

　　20. Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu, Han-Dong Sun*, Triterpenoids from the Schisandraceae family, Natural Product Reports, 2008, 25, 871-891.

　　21. Wei-Lie Xiao, Chun Lei, Jie Ren, Tou-Gen Liao, Jian-Xin Pu, Charles U. Pittman Jr., Yang Lu, Yong-Tang Zheng, Hua-Jie Zhu*, Han-Dong Sun*, Structure Elucidation and Theoretical Investigation of Key Steps in the Biogenetic Pathway of Schisanartane Nortriterpenoids by Using DFT Methods, Chemistry-A European Journal, 2008, 14 (36), 11584-11592.

　　22. Chun Lei, Sheng-Xiong Huang, Ji-Jun Chen, Li-Bin Yang, Wei-Lie Xiao, Yin Chang, Yang Lu, Hao Huang, Jian-Xin Pu, Han-Dong Sun*, Propindilactones E–J, Schiartane Nortriterpenoids from Schisandra propinqua var. Propinqua, J. Nat. Prod., 2008, 71 (7), 1228-1232.

　　23. Li-Mei Li, Guo-You Li, Li-Sheng Ding, Li-Bin Yang, Yong Zhao, Jian-Xin Pu, Wei-Lie Xiao, Quan-Bin Han, and Han-Dong Sun*, ent-Kaurane Diterpenoids from Isodon nervosus, J. Nat. Prod., 2008, 71, 684-688.

　　24. Xue-Mei Gao, Jian-Xin Pu, Sheng-Xiong Huang, Liu-Meng Yang, Hao Huang, Wei-Lie Xiao,Yong-Tang Zheng, Han-Dong Sun*, Lignans from Kadsura angustifolia, J. Nat. Prod., 2008, 71, 558-563.

　　25. Jian-Xin Pu, Liu-Meng Yang, Wei-Lie Xiao, Rong-Tao Li, Chun Lei, Xue-Mei Gao, Sheng-Xiong Huang, Sheng-Hong Li, Yong-Tang Zheng, Hao Huang, Han-Dong Sun*, Compounds from Kadsura heteroclita and Related anti-HIV activity, Phytochemistry, 2008, 69 (5), 1266-1272.

　　26. Li-Bin Yang, Jing Yang, Li-Mei Li, Chun Lei, Yong Zhao, Sheng-Xiong Huang, Wei-Lie Xiao, Quan-Bin Han, Jian-Xin Pu, Han-Dong Sun*, Symmetric and asymmetric ent-kaurane dimmers isolated from Isodon japonicus, Tetrahedron Letters, 2008, 49, 3574-3577.

　　27. Wei-Lie Xiao, Sheng-Xiong Huang, Rui-Rui Wang, Jia-Liang Zhong, Xue-Mei Gao, Fei He, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun*, Nortriterpenoids and lignans from Schisandra sphenanthera, Phytochemistry, 2008, 69, 2862-2866.

　　28. Xue-Mei Gao, Jian-Xin Pu, Wei-Lie Xiao, Sheng-Xiong Huang, Li-Guang Lou, Han-Dong Sun*, Kadcoccilactones K–R, triterpenoids from Kadsura coccinea, Tetrahedron, 2008, 64, 11673-11679.

　　承担科研项目情况：

　　1.国家自然科学基金：五种香茶菜属植物的化学和生物活性成分研究(0701B51211)和五种四川、西藏产五味子属药用植物的化学成分及抗艾滋病活性研究 (0801691211)

　　2.云南省新药研发科技项目：治疗艾滋病中药、天然药物1类新药五味子素胶囊的临床前研究(0703C01211)和抗癌中药、天然药物一类新药毛萼乙素注射剂的临床前研究

　　3.国家自然科学基金重点：五味子科植物新奇化合物的发现及生物活性研究(0801901211)

　　4.NSFC-云南联合基金(重点项目)：云南特有香茶菜属植物中抗癌活性成分及其作用机制研究(0801901211)

　　5.973项目：中国特有植物和微生物药用活性物质的基础研究(2009CB522303)和具有干细胞调控活性的天然产物的挑选和收集(2009CB940900)